Efficacy of Activated Charcoal in the Reduction of Hepatotoxic Effects of Verrucarin J in Mice
نویسندگان
چکیده
To evaluate the effectiveness of activated charcoal in alleviating Verrucarin J, two treated groups of 10 male albino mice were treated with a sublethal dose (0.9mg/kg body weight orally) for two weeks in combination with or without activated charcoal. Highly significant increase in plasma level of lipid peroxidation (LPO), liver disease is often clinically assessed using serum enzyme activites such as glutamate oxaloacetate transaminase (AST), glutamate pyruvate transaminase (ALT), γ-glutamyl transferase (γGT), alkaline phosphatase (ALP), the level of these enzymes were increased significantly in serum of treated group with Verrucarin J and significant decrease of plasma level of antioxidants enzymes and total thiols. In tissue homogenate of liver, level of thiobarbituric acid (TBARs) were significantly increases while activities of superoxide dismutase (SOD) and catalase (CAT) and hepatic glutathione were significantly decreased. Addition of charcoal (1g/kg) to Verrucarin J contaminated diets appeared the adverse effect of toxin. The result indicates that charcoal may be used as antioxidant and antidote for Verrucarin J in male albino mice.
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